Sleep deficits but no metabolic deficits in premanifest H untington's disease

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Sleep deficits but no metabolic deficits in premanifest Huntington's disease

OBJECTIVE Huntington disease (HD) is a fatal autosomal dominant, neurodegenerative condition characterized by progressively worsening motor and nonmotor problems including cognitive and neuropsychiatric disturbances, along with sleep abnormalities and weight loss. However, it is not known whether sleep disturbances and metabolic abnormalities underlying the weight loss are present at a premanif...

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OBJECTIVES Visuospatial processing deficits have been reported in Huntington's disease (HD). To date, no study has examined associations between visuospatial cognition and posterior brain findings in HD. METHODS We compared 119 premanifest (55> and 64<10.8 years to expected disease onset) and 104 early symptomatic (59 stage-1 and 45 stage-2) gene carriers, with 110 controls on visual search a...

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Novel Nut and Bolt Task Quantifies Motor Deficits in Premanifest and Manifest Huntington’s Disease

BACKGROUND We investigated the use of a simple novel nut and bolt task in premanifest and manifest Huntington's disease (HD) patients to detect and quantify motor impairments at all stages of the disease. METHODS Premanifest HD (n=24), manifest HD (n=27) and control (n=32) participants were asked to screw a nut onto a bolt in one direction, using three different sized bolts with their left an...

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Novel Nut and Bolt Task Quantifies Motor Deficits in Premanifest and Manifest HuntingtonTMs Disease Œ PLOS Currents Huntington Disease

Background: We investigated the use of a simple novel nut and bolt task in premanifest and manifest Huntington’s disease (HD) patients to detect and quantify motor impairments at all stages of the disease. Methods: Premanifest HD (n=24), manifest HD (n=27) and control (n=32) participants were asked to screw a nut onto a bolt in one direction, using three different sized bolts with their left an...

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Insular strokes cause no vestibular deficits.

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ژورنال

عنوان ژورنال: Annals of Neurology

سال: 2015

ISSN: 0364-5134,1531-8249

DOI: 10.1002/ana.24495